I’ve had this a couple of times now and it’s pretty annoying. Chrome seems to get stuck on desktop 2, in full screen presentation mode. Pressing the exit full screen button on the right of the menu bar doesn’t do anything and nor does F11 or Shift-CMD-F, the Exit Presentation Mode option in the View menu is also greyed out. I have multiple monitors and I’m not quite sure what’s triggered it, but there is a bug report for it here. I haven’t restarted to trigger the issue, it’s been something else both times. When it’s happened to me I’ve managed to fix it by resetting Chrome’s settings. Hopefully the issue will be resolved in the next update, as it’s rather annoying.